Denver Energy Center is located at the top of the 16th Street Mall between Broadway and Court Street, and within close proximity to LoDo, providing tenants of the building easy access to downtown restaurants, retail and businesses.

The Denver Pavilions mall is two blocks north on 16th Street. RTD provides free shuttle service up and down the mall. The building is within blocks from the California and Champa Light Rail Stations for commuters serving both northbound and southbound lines and Civic center bus station is directly across Broadway.